An outstanding primer that readers should put into the hands of their doctors.
A professor of medicine at the University of Pennsylvania delivers a lucid, opinionated history of the science, politics, and care involved in the fight against this century’s most problematic disease.
The first symptom of Alzheimer’s is usually difficulty with memory, often recognized by a spouse, friend, or caregiver. Over years, memory deteriorates, and victims can no longer perform simple tasks such as paying bills or taking medicine. As the disease worsens, they become apathetic or delusional; lose the ability to dress, feed, and clean themselves; become bedridden and depressed; and often die from complications. Caring for an affected spouse or parent is a crushing experience, often bankrupting all but the wealthy because medical insurance and Medicare pay for medicine and doctor visits but not “custodial care,” which is estimated at as many as 170 hours per month. As Karlawish shows, Alzheimer’s usually causes more suffering for the caregiver than the patient. Until the 1970s, most doctors explained that this was “senility,” a consequence of aging beyond the scope of medical science. Eventually, researchers realized they were dealing with an epidemic of brain disease. At the same time, patient advocacy groups formed to lobby Congress, which was amenable to providing funding. Formerly, doctors diagnosed Alzheimer’s by examining the brain after death. Observing and testing living patients was a major advance. In 2012, the FDA approved an ingenious brain scan that illuminates the areas damaged by Alzheimer’s. Sadly, Medicare won’t pay for the $3,000 test, which doesn’t directly help patients because no good treatment exists (several drugs purport to slow its progress, but many experts believe they’re worthless). A medical expert with a page-turning style, Karlawish is mostly successful in conveying optimism. Hopeful drugs are in the research pipeline, but even better news is that physicians, institutions, and advocacy organizations are adopting more imaginative and humane programs to care for victims both before and after their disease becomes crippling.
An outstanding primer that readers should put into the hands of their doctors.Pub Date: Feb. 23, 2021
ISBN: 978-1-250-21873-5
Page Count: 336
Publisher: St. Martin's
Review Posted Online: Nov. 4, 2020
Kirkus Reviews Issue: Dec. 1, 2020
A hopeful civic sermon favoring inspiration over concrete prescriptions.
A New Jersey senator’s moral manifesto.
Booker situates his narrative in the wake of his 2025 record-breaking 25-hour stand on the Senate floor, an act of physical endurance and moral insistence that serves as its animating example. Though not framed as memoir, the episode implicitly positions Booker himself as a model of the virtues he argues are essential to democratic life. Organized around 10 qualities, including agency, vulnerability, truth, perseverance, and grace, the book advances a clear thesis. “In this book, I argue that many Americans who came before us, and many among us today, have consistently proven that virtues are practical: They expand our power, deepen our sense of belonging, and equip us to endure and ultimately prevail.” Booker illustrates this claim through figures such as the late U.S. Rep. John Lewis, whose willingness to endure sacrifice for principle anchors the book’s moral lineage, and Supreme Court Justice Ketanji Brown Jackson, whose composure under public scrutiny is presented as an example of dignity as civic strength. These portraits reinforce Booker’s belief that character, sustained over time, can shape public life, even when political outcomes remain uncertain or incomplete. He supplements these examples with personal stories drawn from family, faith, and community, delivered with emotional conviction and a tone that remains affirming and carefully calibrated. Much of the narrative reads like an expansive commencement address, earnest and reassuring, offering moral affirmation at moments when readers might reasonably expect sharper confrontation. That rhetorical choice ultimately defines the book’s limits. Booker acknowledges political conflict and compromise, but rarely examines them in depth, and while urging leaders to take moral risks, he avoids sustained reflection on how some of his own political decisions have tested the virtues he promotes. The result is a principled but self-conscious work that affirms shared values while offering little guidance for navigating power and accountability.
A hopeful civic sermon favoring inspiration over concrete prescriptions.Pub Date: March 24, 2026
ISBN: 9781250436733
Page Count: 272
Publisher: St. Martin's
Review Posted Online: March 24, 2026
Kirkus Reviews Issue: March 15, 2026
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular...
A neurosurgeon with a passion for literature tragically finds his perfect subject after his diagnosis of terminal lung cancer.
Writing isn’t brain surgery, but it’s rare when someone adept at the latter is also so accomplished at the former. Searching for meaning and purpose in his life, Kalanithi pursued a doctorate in literature and had felt certain that he wouldn’t enter the field of medicine, in which his father and other members of his family excelled. “But I couldn’t let go of the question,” he writes, after realizing that his goals “didn’t quite fit in an English department.” “Where did biology, morality, literature and philosophy intersect?” So he decided to set aside his doctoral dissertation and belatedly prepare for medical school, which “would allow me a chance to find answers that are not in books, to find a different sort of sublime, to forge relationships with the suffering, and to keep following the question of what makes human life meaningful, even in the face of death and decay.” The author’s empathy undoubtedly made him an exceptional doctor, and the precision of his prose—as well as the moral purpose underscoring it—suggests that he could have written a good book on any subject he chose. Part of what makes this book so essential is the fact that it was written under a death sentence following the diagnosis that upended his life, just as he was preparing to end his residency and attract offers at the top of his profession. Kalanithi learned he might have 10 years to live or perhaps five. Should he return to neurosurgery (he could and did), or should he write (he also did)? Should he and his wife have a baby? They did, eight months before he died, which was less than two years after the original diagnosis. “The fact of death is unsettling,” he understates. “Yet there is no other way to live.”
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular clarity.Pub Date: Jan. 19, 2016
ISBN: 978-0-8129-8840-6
Page Count: 248
Publisher: Random House
Review Posted Online: Sept. 29, 2015
Kirkus Reviews Issue: Oct. 15, 2015
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