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THE GENESIS MACHINE

OUR QUEST TO REWRITE LIFE IN THE AGE OF SYNTHETIC BIOLOGY

A wrinkle on the near future that many readers will not have pondered—and should.

A look at the coming revolution in biotechnology, with all its possible goods and evils.

“A great transformation of life is underway,” write futurist Webb and geneticist Hessel. The rising field of synthetic biology, with its underlying technology of gene editing, will allow for numerous things that do not yet exist, including the ability to sequence the genome of a virus nearly immediately, affording scientists a vast library of viruses that will provide the wherewithal to “cure any genetic disease in humankind.” That revolution, the authors write, will remake food, energy, transportation, the supply chain, and commerce as a whole. Granted, write Webb and Hessel, this is a vast Pandora’s box. Synthetic biology is largely the province of corporations and governments in the developed world, and it is not outside the realm of reason to think that a corporation might maximize profit or a government, political gain through its ability to control the food supply and indeed the genetic library of the planet. The problem, as the authors note in deeply researched but accessible prose, is that there is little in the way of coherence in terms of international agreements or “consensus on the acceptable circumstances under which humans should manipulate human, animal, or plant life.” Part of that problem is the generally laissez faire attitude of some governments, especially the U.S., to develop regulations that “don’t intervene until there’s a problem, so as not to stifle innovations.” Because the current regulatory climate isn’t well structured for future-proofing, one important step is the development of a body of law and convention acknowledging that “this new approach to biology warrants a new approach to regulation,” balancing the public good with scientific and commercial interests. The authors propose planks of a platform to this end while noting the difficulty of reining in tech-driven countries such as China to honor international licensing systems and other controls.

A wrinkle on the near future that many readers will not have pondered—and should.

Pub Date: Feb. 15, 2022

ISBN: 978-1-5417-9791-8

Page Count: 368

Publisher: PublicAffairs

Review Posted Online: Nov. 26, 2021

Kirkus Reviews Issue: Dec. 15, 2021

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ELON MUSK

Alternately admiring and critical, unvarnished, and a closely detailed account of a troubled innovator.

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A warts-and-all portrait of the famed techno-entrepreneur—and the warts are nearly beyond counting.

To call Elon Musk (b. 1971) “mercurial” is to undervalue the term; to call him a genius is incorrect. Instead, Musk has a gift for leveraging the genius of others in order to make things work. When they don’t, writes eminent biographer Isaacson, it’s because the notoriously headstrong Musk is so sure of himself that he charges ahead against the advice of others: “He does not like to share power.” In this sharp-edged biography, the author likens Musk to an earlier biographical subject, Steve Jobs. Given Musk’s recent political turn, born of the me-first libertarianism of the very rich, however, Henry Ford also comes to mind. What emerges clearly is that Musk, who may or may not have Asperger’s syndrome (“Empathy did not come naturally”), has nurtured several obsessions for years, apart from a passion for the letter X as both a brand and personal name. He firmly believes that “all requirements should be treated as recommendations”; that it is his destiny to make humankind a multi-planetary civilization through innovations in space travel; that government is generally an impediment and that “the thought police are gaining power”; and that “a maniacal sense of urgency” should guide his businesses. That need for speed has led to undeniable successes in beating schedules and competitors, but it has also wrought disaster: One of the most telling anecdotes in the book concerns Musk’s “demon mode” order to relocate thousands of Twitter servers from Sacramento to Portland at breakneck speed, which trashed big parts of the system for months. To judge by Isaacson’s account, that may have been by design, for Musk’s idea of creative destruction seems to mean mostly chaos.

Alternately admiring and critical, unvarnished, and a closely detailed account of a troubled innovator.

Pub Date: Sept. 12, 2023

ISBN: 9781982181284

Page Count: 688

Publisher: Simon & Schuster

Review Posted Online: Sept. 12, 2023

Kirkus Reviews Issue: Oct. 15, 2023

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THE RIGHT STUFF

Yes: it's high time for a de-romanticized, de-mythified, close-up retelling of the U.S. Space Program's launching—the inside story of those first seven astronauts.

But no: jazzy, jivey, exclamation-pointed, italicized Tom Wolfe "Mr. Overkill" hasn't really got the fight stuff for the job. Admittedly, he covers all the ground. He begins with the competitive, macho world of test pilots from which the astronauts came (thus being grossly overqualified to just sit in a controlled capsule); he follows the choosing of the Seven, the preparations for space flight, the flights themselves, the feelings of the wives; and he presents the breathless press coverage, the sudden celebrity, the glorification. He even throws in some of the technology. But instead of replacing the heroic standard version with the ring of truth, Wolfe merely offers an alternative myth: a surreal, satiric, often cartoony Wolfe-arama that, especially since there isn't a bit of documentation along the way, has one constantly wondering if anything really happened the way Wolfe tells it. His astronauts (referred to as "the brethren" or "The True Brothers") are obsessed with having the "right stuff" that certain blend of guts and smarts that spells pilot success. The Press is a ravenous fool, always referred to as "the eternal Victorian Gent": when Walter Cronkite's voice breaks while reporting a possible astronaut death, "There was the Press the Genteel Gent, coming up with the appropriate emotion. . . live. . . with no prompting whatsoever!" And, most off-puttingly, Wolfe presumes to enter the minds of one and all: he's with near-drowing Gus Grissom ("Cox. . . That face up there!—it's Cox. . . Cox knew how to get people out of here! . . . Cox! . . ."); he's with Betty Grissom angry about not staying at Holiday Inn ("Now. . . they truly owed her"); and, in a crude hatchet-job, he's with John Glenn furious at Al Shepard's being chosen for the first flight, pontificating to the others about their licentious behavior, or holding onto his self-image during his flight ("Oh, yes! I've been here before! And I am immune! I don't get into corners I can't get out of! . . . The Presbyterian Pilot was not about to foul up. His pipeline to dear Lord could not be clearer"). Certainly there's much here that Wolfe is quite right about, much that people will be interested in hearing: the P-R whitewash of Grissom's foul-up, the Life magazine excesses, the inter-astronaut tensions. And, for those who want to give Wolfe the benefit of the doubt throughout, there are emotional reconstructions that are juicily shrill.

But most readers outside the slick urban Wolfe orbit will find credibility fatally undermined by the self-indulgent digressions, the stylistic excesses, and the broadly satiric, anti-All-American stance; and, though The Right Stuff has enough energy, sass, and dirt to attract an audience, it mostly suggests that until Wolfe can put his subject first and his preening writing-persona second, he probably won't be a convincing chronicler of anything much weightier than radical chic.

Pub Date: Sept. 24, 1979

ISBN: 0312427565

Page Count: 370

Publisher: Farrar, Straus and Giroux

Review Posted Online: Oct. 13, 2011

Kirkus Reviews Issue: Sept. 1, 1979

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