A fascinating look at cutting-edge research with profound implications.
How the brain’s microglial cells affect the body and the mind.
From 2001 to 2006, science journalist Jackson Nakazawa (Childhood Disrupted: How Your Biography Becomes Your Biology and How You Can Heal, 2015, etc.) was stricken, for the second time, with Guillain-Barré syndrome, an autoimmune disease that attacks nerves, causing paralysis. As she recovered, she experienced cognitive and psychological changes that urged her to question the connection between physical immune dysfunction and brain-related and psychiatric illness, a connection that went against the prevailing medical belief that the brain could not be affected by immune disorders. The author’s investigations led her to the work of scientists across many disciplines—neurobiology, genetics, psychology, psychiatry, medicine, and immunology—several of whom she profiles in lively detail: the caffeine-fueled Beth Stevens, for one, a MacArthur fellow who directs a laboratory, and Jonathan Kipnis, whose graduate school professors, decades ago, did not encourage his experiments in the immune system–brain connection. Translating scientific research into brisk, readable prose, Jackson Nakazawa reports on breakthrough discoveries regarding microglial cells, which function as the brain’s white blood cells, with “enormous power to protect, repair, and repopulate the brain’s billions of neurons and trillions of synapses, or to cripple and destroy them.” But besides functioning as helpful “angels,” they also can spin into overdrive in response to stressors such as infection, environmental toxins, trauma, physical or emotional abuse, and chronic mental stress. When these stressors appear to microglia as if they are biological pathogens, the resulting “frenzied” microglial activity can lead to depression, anxiety, cognitive impairment, forgetfulness, lethargy, and similar symptoms. The author follows three autoimmune sufferers whose psychological symptoms were significantly improved by one of the new therapies resulting from microglial research: transcranial magnetic stimulation, neurofeedback, gamma light therapy, and fasting diets. Scientists in many fields, writes the author, are looking into a microglial connection to Alzheimer’s disease, with the hope that if the cells can be rebooted and reprogrammed, they can “help reverse the ravages” of the disease.
A fascinating look at cutting-edge research with profound implications.Pub Date: Jan. 21, 2020
ISBN: 978-1-5247-9917-5
Page Count: 320
Publisher: Ballantine
Review Posted Online: Dec. 21, 2019
Kirkus Reviews Issue: Jan. 15, 2020
BOOK REVIEW
Skloot's meticulous, riveting account strikes a humanistic balance between sociological history, venerable portraiture and...
A dense, absorbing investigation into the medical community's exploitation of a dying woman and her family's struggle to salvage truth and dignity decades later.
In a well-paced, vibrant narrative, Popular Science contributor and Culture Dish blogger Skloot (Creative Writing/Univ. of Memphis) demonstrates that for every human cell put under a microscope, a complex life story is inexorably attached, to which doctors, researchers and laboratories have often been woefully insensitive and unaccountable. In 1951, Henrietta Lacks, an African-American mother of five, was diagnosed with what proved to be a fatal form of cervical cancer. At Johns Hopkins, the doctors harvested cells from her cervix without her permission and distributed them to labs around the globe, where they were multiplied and used for a diverse array of treatments. Known as HeLa cells, they became one of the world's most ubiquitous sources for medical research of everything from hormones, steroids and vitamins to gene mapping, in vitro fertilization, even the polio vaccine—all without the knowledge, must less consent, of the Lacks family. Skloot spent a decade interviewing every relative of Lacks she could find, excavating difficult memories and long-simmering outrage that had lay dormant since their loved one's sorrowful demise. Equal parts intimate biography and brutal clinical reportage, Skloot's graceful narrative adeptly navigates the wrenching Lack family recollections and the sobering, overarching realities of poverty and pre–civil-rights racism. The author's style is matched by a methodical scientific rigor and manifest expertise in the field.
Skloot's meticulous, riveting account strikes a humanistic balance between sociological history, venerable portraiture and Petri dish politics.Pub Date: Feb. 9, 2010
ISBN: 978-1-4000-5217-2
Page Count: 320
Publisher: Crown
Review Posted Online: Dec. 22, 2010
Kirkus Reviews Issue: Jan. 1, 2010
BOOK REVIEW
An absorbing, wide-ranging story of humans’ relationship with the water.
A study of swimming as sport, survival method, basis for community, and route to physical and mental well-being.
For Bay Area writer Tsui (American Chinatown: A People's History of Five Neighborhoods, 2009), swimming is in her blood. As she recounts, her parents met in a Hong Kong swimming pool, and she often visited the beach as a child and competed on a swim team in high school. Midway through the engaging narrative, the author explains how she rejoined the team at age 40, just as her 6-year-old was signing up for the first time. Chronicling her interviews with scientists and swimmers alike, Tsui notes the many health benefits of swimming, some of which are mental. Swimmers often achieve the “flow” state and get their best ideas while in the water. Her travels took her from the California coast, where she dove for abalone and swam from Alcatraz back to San Francisco, to Tokyo, where she heard about the “samurai swimming” martial arts tradition. In Iceland, she met Guðlaugur Friðþórsson, a local celebrity who, in 1984, survived six hours in a winter sea after his fishing vessel capsized, earning him the nickname “the human seal.” Although humans are generally adapted to life on land, the author discovered that some have extra advantages in the water. The Bajau people of Indonesia, for instance, can do 10-minute free dives while hunting because their spleens are 50% larger than average. For most, though, it’s simply a matter of practice. Tsui discussed swimming with Dara Torres, who became the oldest Olympic swimmer at age 41, and swam with Kim Chambers, one of the few people to complete the daunting Oceans Seven marathon swim challenge. Drawing on personal experience, history, biology, and social science, the author conveys the appeal of “an unflinching giving-over to an element” and makes a convincing case for broader access to swimming education (372,000 people still drown annually).
An absorbing, wide-ranging story of humans’ relationship with the water.Pub Date: April 14, 2020
ISBN: 978-1-61620-786-1
Page Count: 288
Publisher: Algonquin
Review Posted Online: Jan. 4, 2020
Kirkus Reviews Issue: Feb. 1, 2020
BOOK REVIEW
BOOK REVIEW
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