A readable, provocative look at biological tinkering that will doubtless shape the future, whether we like it or not.
Lucid study of recent efforts to alter the human gene to end hereditary diseases, a project fraught with ethical and medical implications.
Kirksey, an anthropologist who is often called upon to speak to humanistic, rather than strictly biological, views of human nature, explores a most human problem: the use of the new CRISPR technology to alter genes to remove undesirable features. “CRISPR is an enzyme that produces targeted mutagenesis,” he writes. “In other words, CRISPR generates mutants.” These mutants are not yet at the level of the famed X-Men, though they touch on a point in common. As Kirksey observes, the X-Men series “was created by two American Jewish men in 1963 as a parable about civil rights.” And what of the civil rights of the gene-edited babies produced recently in a Chinese laboratory? They have been carefully hidden away, for “the families desperately wanted to protect the identity of their children to prevent discriminatory treatment by society.” Kirksey’s primary narrative follows Jiankui He, the Chinese scientist responsible for the in vitro gene-edited procedure that produced a set of twins. Dr. He, a brilliant man who raised himself out of poverty through sheer effort, may have started with the best of intentions, but the gene-editing enterprise quickly became a profit center snapped up by excited corporations. Editing, writes the author, may not be the best metaphor: “CRISPR is more like a tiny Reaper drone that can produce targeted damage to DNA,” sometimes hitting precisely and sometimes inadvertently destroying good cells on either side. Whatever the case, scientists are already looking at eliminating existing mutations, “from primordial dwarfism to obscure conditions like CAMRQ (cerebellar ataxia, intellectual disability, and dysequilibrium syndrome),” a business without visible end and, of course, available first to those with the greatest financial resources.
A readable, provocative look at biological tinkering that will doubtless shape the future, whether we like it or not.Pub Date: Nov. 10, 2020
ISBN: 978-1-250-26535-7
Page Count: 304
Publisher: St. Martin's
Review Posted Online: Sept. 28, 2020
Kirkus Reviews Issue: Oct. 15, 2020
A virtuoso performance and an ode to an undervalued medium created by two talented artists.
The veteran actor, comedian, and banjo player teams up with the acclaimed illustrator to create a unique book of cartoons that communicates their personalities.
Martin, also a prolific author, has always been intrigued by the cartoons strewn throughout the pages of the New Yorker. So when he was presented with the opportunity to work with Bliss, who has been a staff cartoonist at the magazine since 1997, he seized the moment. “The idea of a one-panel image with or without a caption mystified me,” he writes. “I felt like, yeah, sometimes I’m funny, but there are these other weird freaks who are actually funny.” Once the duo agreed to work together, they established their creative process, which consisted of working forward and backward: “Forwards was me conceiving of several cartoon images and captions, and Harry would select his favorites; backwards was Harry sending me sketched or fully drawn cartoons for dialogue or banners.” Sometimes, he writes, “the perfect joke occurs two seconds before deadline.” There are several cartoons depicting this method, including a humorous multipanel piece highlighting their first meeting called “They Meet,” in which Martin thinks to himself, “He’ll never be able to translate my delicate and finely honed droll notions.” In the next panel, Bliss thinks, “I’m sure he won’t understand that the comic art form is way more subtle than his blunt-force humor.” The team collaborated for a year and created 150 cartoons featuring an array of topics, “from dogs and cats to outer space and art museums.” A witty creation of a bovine family sitting down to a gourmet meal and one of Dumbo getting his comeuppance highlight the duo’s comedic talent. What also makes this project successful is the team’s keen understanding of human behavior as viewed through their unconventional comedic minds.
A virtuoso performance and an ode to an undervalued medium created by two talented artists.Pub Date: Nov. 17, 2020
ISBN: 978-1-250-26289-9
Page Count: 272
Publisher: Celadon Books
Review Posted Online: Aug. 30, 2020
Kirkus Reviews Issue: Sept. 15, 2020
PERSPECTIVES
An ebullient nature lover’s paean to birds.
A charming bird journey with the bestselling author.
In his introduction to Tan’s “nature journal,” David Allen Sibley, the acclaimed ornithologist, nails the spirit of this book: a “collection of delightfully quirky, thoughtful, and personal observations of birds in sketches and words.” For years, Tan has looked out on her California backyard “paradise”—oaks, periwinkle vines, birch, Japanese maple, fuchsia shrubs—observing more than 60 species of birds, and she fashions her findings into delightful and approachable journal excerpts, accompanied by her gorgeous color sketches. As the entries—“a record of my life”—move along, the author becomes more adept at identifying and capturing them with words and pencils. Her first entry is September 16, 2017: Shortly after putting up hummingbird feeders, one of the tiny, delicate creatures landed on her hand and fed. “We have a relationship,” she writes. “I am in love.” By August 2018, her backyard “has become a menagerie of fledglings…all learning to fly.” Day by day, she has continued to learn more about the birds, their activities, and how she should relate to them; she also admits mistakes when they occur. In December 2018, she was excited to observe a Townsend’s Warbler—“Omigod! It’s looking at me. Displeased expression.” Battling pesky squirrels, Tan deployed Hot Pepper Suet to keep them away, and she deterred crows by hanging a fake one upside down. The author also declared war on outdoor cats when she learned they kill more than 1 billion birds per year. In May 2019, she notes that she spends $250 per month on beetle larvae. In June 2019, she confesses “spending more hours a day staring at birds than writing. How can I not?” Her last entry, on December 15, 2022, celebrates when an eating bird pauses, “looks and acknowledges I am there.”
An ebullient nature lover’s paean to birds.Pub Date: April 23, 2024
ISBN: 9780593536131
Page Count: 320
Publisher: Knopf
Review Posted Online: Jan. 19, 2024
Kirkus Reviews Issue: Feb. 15, 2024
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