A smart, engrossing tale that entertainingly uses science.
A genetic algorithm intended as a cure for cancer becomes part of someone’s nefarious and deadly experiments in this techno-thriller.
After losing both parents to cancer, oncologist Dr. Juan Gutierrez devoted his life to finding a cure. While researching generations of species at the pharmaceutical company AgriMed, Juan uncovers an evolutionary pattern. From this, he derives an algorithm that he hopes will combat cancer. Meanwhile, FBI Special Agent Nate Carrington is investigating cases of lethal attacks by animals, such as dogs and birds. These cases are linked by the animals’ DNA evidence, which suggests some form of genetic manipulation. Nate soon determines that someone has pilfered Juan’s algorithm for experiments that ultimately include human subjects. To make matters worse, the stolen algorithm is an older, less stable version and leads to a number of people becoming infected with a life-threatening virus. One of the stricken may be Juan’s new romantic interest, Kathy O’Reilly, who happens to be a survivor of an animal attack. She and her Nevada rancher parents, Frank and Megan, are unwitting participants in an experiment that puts many in danger. Nate and Juan have little time to find the culprit and a cure before the death count among humans starts rising exponentially. Rothman’s (Perimeter, 2018, etc.) tale moves at a steady clip. Dialogue, in particular, is concise; in one scene, Juan converses with his boss over the phone and police officers in person, and the concurrent exchanges are clear and coherent. Scientific terminology is likewise comprehensible, thanks to the author supplying context or Juan simply explaining terms to an individual. While characters are dynamic, especially the O’Reillys, the most memorable is Jasper, a stray dog Frank and Megan take in. Readers know from the beginning that the hyper-intelligent canine is a lab escapee. But despite Jasper’s tie to the experiments, Rothman zeros in on his empathy and fierce loyalty, traits that make his human counterparts even more likable. In useful addenda, the author elucidates on two subjects from the narrative, genetically modified organisms and gene therapy.
A smart, engrossing tale that entertainingly uses science.Pub Date: Feb. 15, 2019
ISBN: 978-1-79027-123-8
Page Count: 352
Publisher: Time Tunnel Media
Review Posted Online: March 29, 2019
Review Program: Kirkus Indie
Coelho's placebo has racked up impressive sales in Brazil and Europe. Americans should flock to it like gulls.
Coelho is a Brazilian writer with four books to his credit. Following Diary of a Magus (1992—not reviewed) came this book, published in Brazil in 1988: it's an interdenominational, transcendental, inspirational fable—in other words, a bag of wind.
The story is about a youth empowered to follow his dream. Santiago is an Andalusian shepherd boy who learns through a dream of a treasure in the Egyptian pyramids. An old man, the king of Salem, the first of various spiritual guides, tells the boy that he has discovered his destiny: "to realize one's destiny is a person's only real obligation." So Santiago sells his sheep, sails to Tangier, is tricked out of his money, regains it through hard work, crosses the desert with a caravan, stops at an oasis long enough to fall in love, escapes from warring tribesmen by performing a miracle, reaches the pyramids, and eventually gets both the gold and the girl. Along the way he meets an Englishman who describes the Soul of the World; the desert woman Fatima, who teaches him the Language of the World; and an alchemist who says, "Listen to your heart" A message clings like ivy to every encounter; everyone, but everyone, has to put in their two cents' worth, from the crystal merchant to the camel driver ("concentrate always on the present, you'll be a happy man"). The absence of characterization and overall blandness suggest authorship by a committee of self-improvement pundits—a far cry from Saint- Exupery's The Little Prince: that flagship of the genre was a genuine charmer because it clearly derived from a quirky, individual sensibility.
Coelho's placebo has racked up impressive sales in Brazil and Europe. Americans should flock to it like gulls.Pub Date: July 1, 1993
ISBN: 0-06-250217-4
Page Count: 192
Publisher: N/A
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: May 1, 1993
SEEN & HEARD
SEEN & HEARD
BOOK TO SCREEN
The phrase “tour de force” could have been invented for this audacious novel.
Four men who meet as college roommates move to New York and spend the next three decades gaining renown in their professions—as an architect, painter, actor and lawyer—and struggling with demons in their intertwined personal lives.
Yanagihara (The People in the Trees, 2013) takes the still-bold leap of writing about characters who don’t share her background; in addition to being male, JB is African-American, Malcolm has a black father and white mother, Willem is white, and “Jude’s race was undetermined”—deserted at birth, he was raised in a monastery and had an unspeakably traumatic childhood that’s revealed slowly over the course of the book. Two of them are gay, one straight and one bisexual. There isn’t a single significant female character, and for a long novel, there isn’t much plot. There aren’t even many markers of what’s happening in the outside world; Jude moves to a loft in SoHo as a young man, but we don’t see the neighborhood change from gritty artists’ enclave to glitzy tourist destination. What we get instead is an intensely interior look at the friends’ psyches and relationships, and it’s utterly enthralling. The four men think about work and creativity and success and failure; they cook for each other, compete with each other and jostle for each other’s affection. JB bases his entire artistic career on painting portraits of his friends, while Malcolm takes care of them by designing their apartments and houses. When Jude, as an adult, is adopted by his favorite Harvard law professor, his friends join him for Thanksgiving in Cambridge every year. And when Willem becomes a movie star, they all bask in his glow. Eventually, the tone darkens and the story narrows to focus on Jude as the pain of his past cuts deep into his carefully constructed life.
The phrase “tour de force” could have been invented for this audacious novel.Pub Date: March 10, 2015
ISBN: 978-0-385-53925-8
Page Count: 720
Publisher: Doubleday
Review Posted Online: Dec. 21, 2014
Kirkus Reviews Issue: Jan. 1, 2015
BOOK REVIEW
BOOK REVIEW
PROFILES
PERSPECTIVES
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