McNeill's global history of infectious disease and its effect on the political destinies of men is built on a stunning analogy: the "microparasitism" of viruses and bacteria—carriers of typhoid, malaria, et al.—is intimately bound up with the "macroparasitism" of human predators, be they Chinese warlords, Roman soldiers, or Spanish conquistadors. Epidemological upheavals produce disarray in political and social structures; conversely microparasitic stability which allows for population growth and food surpluses seems to be a prerequisite of macroparasitic equilibrium. McNeill develops this thesis initially by examining the "disease pools" of ancient China, the Indian subcontinent, and the Mediterranean. Rome's decay between 200 and 600 A.D. demonstrates that when a new disease (in this case smallpox and measles) strikes a previously unexposed population, catastrophic die-offs occur. Much later, the age of oceanic exploration (1450-1550) brought similar cataclysms to Mexico and Peru where the native Amerindian populations (who had no immunity to Eurasia's "common childhood diseases") died off by the millions. Nothing escapes McNeill's reckoning: the Hindu caste system; the impetus epidemics gave to early Christianity which stressed the evanescence of human life and—no small matter—the nursing and care of the sick; the lethal blow which the advent of the bubonic plague in 14th-century Europe dealt to the rational theology of Acquinas; the "disease barrier" which until the 19th century kept the technologically advanced "macroparasites" of European imperialism from effective penetration of Africa. To be sure the scanty and often indecipherable medical writings of the ancient world force McNeill to rely on a great deal of speculation, deduction, and even guesswork. The book will provoke arguments from countless specialists. No matter. Plagues and People, a glorious successor to The Rise of the West, integrates ecology and demography with politics and culture on a vast scale. A brilliantly conceptualized and challenging scholarly achievement.